
COMMISSION REGULATION (EC) No 508/1999 of 4 March 1999 amending Annexes I to IV to Council Regulation (EEC) No 2377/90 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin 

THE COMMISSION OF THE EUROPEAN COMMUNITIES,
Having regard to the Treaty establishing the European Community,
Having regard to Council Regulation (EEC) No 2377/90 of 26 June 1990 laying down a Community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin, as last amended by Commission Regulation (EC) No 2728/98, and in particular Articles 6, 7 and 8 thereof,

Whereas, since the adoption of Regulation (EEC) No 2377/90, the Annexes have been amended a number of times; whereas, since the texts are numerous, complex and dispersed among various Official Journals, they are difficult to use and thus lack the clarity which should be an essential feature of all legislation; whereas, certain of those Annexes should therefore be consolidated; whereas on the same occasion the name or chemical description of some compounds should be rectified or made more precise and certain material errors should be corrected;
Whereas the measures provided for in this Regulation are in accordance with the opinion of the Standing Committee on Veterinary Medicinal Products,
HAS ADOPTED THIS REGULATION:

Article 1 
Annexes I to IV to Regulation (EEC) No 2377/90 are hereby replaced by the texts set out in the Annex to this Regulation.
Article 2 
This Regulation shall enter into force on the 60th day following that of its publication in the Official Journal of the European Communities.
This Regulation shall be binding in its entirety and directly applicable in all Member States.
ANNEX I
LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES FOR WHICH MAXIMUM RESIDUE LIMITS HAVE BEEN FIXED

1. Anti-infectious agents
 1.1. Chemotheurapeutics
 1.1.1. Sulfonamides

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
All substances belonging to the sulfonamide group Parent drug All food-producing species 100 μg/kg Muscle The combined total residues of all substances within the sulfonamide group should not exceed 100 μg/kg
   100 μg/kg Fat 
   100 μg/kg Liver 
   100 μg/kg Kidney 
  Bovine, ovine, caprine 100 μg/kg Milk 
 1.1.2. Diamino pyrimidine derivatives

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Baquiloprim Baquiloprim Bovine 10 μg/kg Fat 
   300 μg/kg Liver 
   150 μg/kg Kidney 
   30 μg/kg Milk 
  Porcine 40 μg/kg Skin and fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
Trimethoprim Trimethoprim Bovine 50 μg/kg Muscle 
   50 μg/kg Fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
   50 μg/kg Milk 
  Porcine 50 μg/kg Muscle 
   50 μg/kg Skin and fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
  Equidae 100 μg/kg Muscle 
   100 μg/kg Fat 
   100 μg/kg Liver 
   100 μg/kg Kidney 
  Poultry 50 μg/kg Muscle 
  Not for use in animals from which eggs are produced for human consumption 50 μg/kg Skin and fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
  Fin fish 50 μg/kg Muscle and skin in natural proportions 
 1.2. Antibiotics
 1.2.1. Penicillins

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Amoxicyllin Amoxicyllin All food-producing species 50 μg/kg Muscle 
   50 μg/kg Fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
   4 μg/kg Milk 
Ampicillin Ampicillin All food-producing species 50 μg/kg Muscle 
   50 μg/kg Fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
   4 μg/kg Milk 
Benzylpenicillin Benzylpenicillin All food-producing species 50 μg/kg Muscle 
   50 μg/kg Fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
   4 μg/kg Milk 
Cloxacillin Cloxacillin All food-producing species 300 μg/kg Muscle 
   300 μg/kg Fat 
   300 μg/kg Liver 
   300 μg/kg Kidney 
   30 μg/kg Milk 
Dicloxacillin Dicloxacillin All food-producing species 300 μg/kg Muscle 
   300 μg/kg Fat 
   300 μg/kg Liver 
   300 μg/kg Kidney 
   30 μg/kg Milk 
Oxacillin Oxacillin All food-producing species 300 μg/kg Muscle 
   300 μg/kg Fat 
   300 μg/kg Liver 
   300 μg/kg Kidney 
   30 μg/kg Milk 
Penethamate Benzylpenicillin Bovine 50 μg/kg Muscle 
   50 μg/kg Fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
   4 μg/kg Milk 
 1.2.2. Cephalosporins

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Cefazolin Cefazolin Bovine, ovine, caprine 50 μg/kg Milk 
Cefquinome Cefquinome Bovine 50 μg/kg Muscle 
   50 μg/kg Fat 
   100 μg/kg Liver 
   200 μg/kg Kidney 
   20 μg/kg Milk 
 1.2.3. Quinolones

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Danofloxacin Danofloxacin Bovine 200 μg/kg Muscle 
  Not for use in animals from which milk is produced for human consumption 100 μg/kg Fat 
   400 μg/kg Liver 
   400 μg/kg Kidney 
  Chicken 200 μg/kg Muscle 
  Not for use in animals from which eggs are produced for human consumption 100 μg/kg Skin and fat 
   400 μg/kg Liver 
   400 μg/kg Kidney 
Difloxacin Difloxacin Chicken, turkey 300 μg/kg Muscle 
   400 μg/kg Skin and fat 
   1 900 μg/kg Liver 
   600 μg/kg Kidney 
Enrofloxacin Sum of enrofloxacin and ciprofloxacin Bovine 100 μg/kg Muscle 
   100 μg/kg Fat 
   300 μg/kg Liver 
   200 μg/kg Kidney 
   100 μg/kg Milk 
  Rabbits 100 μg/kg Muscle 
   100 μg/kg Fat 
   200 μg/kg Liver 
   300 μg/kg Kidney 
  Porcine 100 μg/kg Muscle 
   100 μg/kg Skin and fat 
   200 μg/kg Liver 
   300 μg/kg Kidney 
  Poultry 100 μg/kg Muscle 
  Not for use in animals from which eggs are produced for human consumption 100 μg/kg Skin and fat 
   200 μg/kg Liver 
   300 μg/kg Kidney 
Sarafloxacin Sarafloxacin Chicken 10 μg/kg Skin and fat 
   100 μg/kg Liver 
  Salmonidae 30 μg/kg Muscle and skin in natural proportions 
 1.2.4. Macrolides

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Spiramycin Sum of spiramycin and neospiramycin Bovine 200 μg/kg Muscle 
   300 μg/kg Fat 
   300 μg/kg Liver 
   300 μg/kg Kidney 
   200 μg/kg Milk 
  Chicken 200 μg/kg Muscle 
   300 μg/kg Skin and fat 
   400 μg/kg Liver 
Tilmicosin Tilmicosin Bovine, ovine, porcine 50 μg/kg Muscle 
   50 μg/kg Fat 
   1 000 μg/kg Liver 
   1 000 μg/kg Kidney 
  Ovine 50 μg/kg Milk 
  Chicken 75 μg/kg Muscle Not for use in animals from which eggs are produced for human consumption
   75 μg/kg Skin and fat 
   1 000 μg/kg Liver 
   250 μg/kg Kidney 
Tylosin Tylosin A Bovine 100 μg/kg Muscle 
   100 μg/kg Fat 
   100 μg/kg Liver 
   100 μg/kg Kidney 
   50 μg/kg Milk 
  Porcine 100 μg/kg Muscle 
   100 μg/kg Skin and fat 
   100 μg/kg Liver 
   100 μg/kg Kidney 
  Poultry 100 μg/kg Muscle 
  Not for use in hens producing eggs for human consumption 100 μg/kg Skin and fat 
   100 μg/kg Liver 
   100 μg/kg Kidney 
 1.2.5. Florfenicol and related compounds

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Florfenicol Sum of florfenicol and its metabolites measured as florfenicol-amine Bovine 200 μg/kg Muscle 
   3 000 μg/kg Liver 
   300 μg/kg Kidney 
Thiamphenicol Thiamphenicol Bovine 50 μg/kg Muscle 
   50 μg/kg Fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
   50 μg/kg Milk 
  Chicken 50 μg/kg Muscle 
  Not for use in animals from which eggs are produced for human consumption 50 μg/kg Skin and fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
 1.2.6. Tetracyclines

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Chlortetracycline Sum of parent drug and its 4- epimer All food-producing species 100 μg/kg Muscle 
   300 μg/kg Liver 
   600 μg/kg Kidney 
   100 μg/kg Milk 
   200 μg/kg Eggs 
Doxycycline Doxycycline Bovine 100 μg/kg Muscle 
  Not for use in animals from which milk is produced for human consumption 300 μg/kg Liver 
   600 μg/kg Kidney 
  Porcine 100 μg/kg Muscle 
   300 μg/kg Skin and fat 
   300 μg/kg Liver 
   600 μg/kg Kidney 
  Poultry 100 μg/kg Muscle 
  Not for use in animals from which eggs are produced for human consumption 300 μg/kg Skin and fat 
   300 μg/kg Liver 
   600 μg/kg Kidney 
Oxytetracycline Sum of parent drug and its 4-epimer All food-producing species 100 μg/kg Muscle 
   300 μg/kg Liver 
   600 μg/kg Kidney 
   100 μg/kg Milk 
   200 μg/kg Eggs 
Tetracycline Sum of parent drug and its 4-epimer All food-producing species 100 μg/kg Muscle 
   300 μg/kg Liver 
   600 μg/kg Kidney 
   100 μg/kg Milk 
   200 μg/kg Eggs 
 1.2.7. Naphtalene-ringed ansamycin

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Rifaximin Rifaximin Bovine 60 μg/kg Milk 
 1.2.8. Pleuromutilines

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Valnemulin Valnemulin Porcine 50 μg/kg Muscle 
   500 μg/kg Liver 
   100 μg/kg Kidney 

2. Antiparasitic agents
 2.1. Agents acting against endoparasites
 2.1.1. Salicylanilides

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Closantel Closantel Bovine 1 000 μg/kg Muscle 
   3 000 μg/kg Fat 
   1 000 μg/kg Liver 
   3 000 μg/kg Kidney 
  Ovine 1 500 μg/kg Muscle 
   2 000 μg/kg Fat 
   1 500 μg/kg Liver 
   5 000 μg/kg Kidney 
 2.1.2. Tatra-hydro-imidazoles (imidazolthiazoles)

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Levamisole Levamisole Bovine, ovine, porcine, poultry 10 μg/kg Muscle 
   10 μg/kg Fat 
   100 μg/kg Liver 
   10 μg/kg Kidney 
 2.1.3. Benzimidazoles and pro-benzimidazoles

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Albendazole Sum of albendazole sulphoxide, albendazole sulphone, and albendazole 2-amino sulphone, expressed as albendazole Bovine, ovine 100 μg/kg Muscle 
   100 μg/kg Fat 
   1 000 μg/kg Liver 
   500 μg/kg Kidney 
   100 μg/kg Milk 
Febantel Sum of extractable residues which may be oxidised to oxfendazole Bovine, ovine 10 μg/kg Milk 
  Bovine, ovine, porcine, equidae 50 μg/kg Muscle 
   50 μg/kg Fat 
   500 μg/kg Liver 
   50 μg/kg Kidney 
Fenbendazole Sum of extractable residues which may be oxidised to oxfendazole sulphone Bovine, ovine 10 μg/kg Milk 
  Bovine, ovine, porcine, equide 50 μg/kg Muscle 
   50 μg/kg Fat 
   500 μg/kg Liver 
   50 μg/kg Kidney 
Flubendazole Sum of flubendazole and (2-amino 1H-benzimidazol-5-yl) (4fluorophenyl) methanone Porcine, chicken, game birds 50 μg/kg Muscle 
   50 μg/kg Skin and fat 
   400 μg/kg Liver 
   300 μg/kg Kidney 
 Flubendazole Chicken 400 μg/kg Eggs 
Oxfendazole Sum of extractable residues which may be oxidised to oxfendazole sulphone Bovine, ovine 10 μg/kg Milk 
  Bovine, ovine, porcine, equidae 50 μg/kg Muscle 
   50 μg/kg Fat 
   500 μg/kg Liver 
   50 μg/kg Kidney 
Oxibendazole Oxibendazole Porcine 100 μg/kg Muscle 
   500 μg/kg Skin and fat 
   200 μg/kg Liver 
   100 μg/kg Kidney 
Thiabendazole Sum of thiabendazole and 5-hydroxythiabendazole Bovine 100 μg/kg Muscle 
   100 μg/kg Fat 
   100 μg/kg Liver 
   100 μg/kg Kidney 
   100 μg/kg Milk 
Triclabendazole Sum of extractable residues that may be oxidised to ketotriclabendazole Bovine, ovine 100 μg/kg Muscle Not for use in animals from which milk is produced for human consumption
   100 μg/kg Liver 
   100 μg/kg Kidney 
 2.2. Agents acting against ectoparasites
 2.2.1. Organophosphates

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Diazinon Diazinon Bovine, ovine, caprine 20 μg/kg Milk 
  Bovine, porcine, ovine, caprine 20 μg/kg Muscle 
   700 μg/kg Fat 
   20 μg/kg Liver 
   20 μg/kg Kidney 
 2.2.2. Formamidines

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Amitraz Sum of amitraz and all metabolites containing the 2,4-DMA moiety, expressed as amitraz Bovine 200 μg/kg Fat 
   200 μg/kg Liver 
   200 μg/kg Kidney 
   10 μg/kg Milk 
  Ovine 400 μg/kg Fat 
   100 μg/kg Liver 
   200 μg/kg Kidney 
   10 μg/kg Milk 
  Porcine 400 μg/kg Skin and fat 
   200 μg/kg Liver 
   200 μg/kg Kidney 
 2.2.3. Pyrethroids

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Flumethrin Flumethrin (sum of trans-Z isomers) Bovine 10 μg/kg Muscle 
   150 μg/kg Fat 
   20 μg/kg Liver 
   10 μg/kg Kidney 
   30 μg/kg Milk 
 2.3. Agents acting against endo- and ectoparasites
 2.3.1. Avermectins

Phramacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Abamectin Avermectin B1a Bovine 10 μg/kg Fat 
   20 μg/kg Liver 
Doramectin Doramectin Bovine 10 μg/kg Muscle Not for use in bovine from which milk is produced for human consumption
   150 μg/kg Fat 
   100 μg/kg Liver 
   30 μg/kg Kidney 
  Porcine, ovine 20 μg/kg Muscle Not for use in ovine from which milk is produced for human consumption
   100 μg/kg Fat 
   50 μg/kg Liver 
   30 μg/kg Kidney 
Eprinomectin Eprinomectin B1a Bovine 30 μg/kg Muscle 
   30 μg/kg Fat 
   600 μg/kg Liver 
   100 μg/kg Kidney 
   30 μg/kg Milk 
Ivermectin 22, 23-Dihydro-avermectin B1a Bovine 40 μg/kg Fat 
   100 μg/kg Liver 
  Porcine, ovine, equidae 20 μg/kg Fat 
   15 μg/kg Liver 
  Deer, including reindeer 20 μg/kg Muscle 
   100 μg/kg Fat 
   50 μg/kg Liver 
   20 μg/kg Kidney 
Moxidectin Moxidectin Bovine, ovine 50 μg/kg Muscle 
   500 μg/kg Fat 
   100 μg/kg Liver 
   50 μg/kg Kidney 
 2.4. Agents acting against protozoa
 2.4.1. Triazinetrione derivative

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Toltrazuril Toltrazuril sulfone Chicken 100 μg/kg Muscle Not for use in animals from which eggs are produced for human consumption
   200 μg/kg Skin and fat 
   600 μg/kg Liver 
   400 μg/kg Kidney 
  Turkey 100 μg/kg Muscle 
   200 μg/kg Skin and fat 
   600 μg/kg Liver 
   400 μg/kg Kidney 

3. Agents acting on the nervous system
 3.1. Agents acting on the central nervous system
 3.1.1. Butyrophenone tranquillisers

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Azaperone Sum of azaperone and azaperol Porcine 100 μg/kg Muscle 
   100 μg/kg Skin and fat 
   100 μg/kg Liver 
   100 μg/kg Kidney 
 3.2. Agents acting on the autonomic nervous system
 3.2.1. Anti-adrenergics

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Carazolol Carazolol Porcine 5 μg/kg Muscle 
   5 μg/kg Skin and fat 
   25 μg/kg Liver 
   25 μg/kg Kidney 

4. Anti-inflammatory agents
 4.1. Nonsteroidal anti-inflammatory agents
 4.1.1. Arylpropionic acid derivative

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Vedaprofen Vedaprofen Equidae 50 μg/kg Muscle 
   20 μg/kg Fat 
   100 μg/kg Liver 
   1 000 μg/kg Kidney 
 4.1.2. Fenamate group derivatives

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Tolfenamic acid Tolfenamic acid Bovine 50 μg/kg Muscle 
   400 μg/kg Liver 
   100 μg/kg Kidney 
   50 μg/kg Milk 
  Porcine 50 μg/kg Muscle 
   400 μg/kg Liver 
   100 μg/kg Kidney 

5. Corticoides
 5.1. Glucocorticoides

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Dexamethasone Dexamethasone Bovine 0,3 μg/kg Milk 
  Bovine, porcine, equidae 0,75 μg/kg Muscle 
   2 μg/kg Liver 
   0,75 μg/kg Kidney 

ANNEX II
LIST OF SUBSTANCES NOT SUBJECT TO MAXIMUM RESIDUE LIMITS

1. Inorganic chemicals

Pharmacologically active substance(s) Animal species Other provisions
Aluminium distearate All food-producing species 
Aluminium hydroxide acetate All food-producing species 
Aluminium phosphate All food-producing species 
Aluminium tristearate All food-producing species 
Ammonium chloride All food-producing species 
Bismuth subcarbonate All food-producing species For oral use only
Bismuth subgallate All food-producing species For oral use only
Bismuth subnitrate All food-producing species For oral use only
Bismuth subsalicylate All food-producing species For oral use only
Boric acid and borates All food-producing species 
Bromide, sodium salt All mammalian food-producing species For topical use only
Calcium acetateCalcium benzoateCalcium carbonateCalcium chlorideCalcium gluconateCalcium hydroxideCalcium hypophosphiteCalcium malateCalcium oxideCalcium phosphateCalcium polyphosphatesCalcium propionateCalcium silicateCalcium stearateCalcium sulphate All food-producing species 
Calcium glucoheptonate All food-producing species 
Calcium glucono glucoheptonate All food-producing species 
Calcium gluconolactate All food-producing species 
Calcium glutamate All food-producing species 
Cobalt carbonate All food-producing species 
Cobalt dichloride All food-producing species 
Cobalt gluconate All food-producing species 
Cobalt oxide All food-producing species 
Cobalt sulphate All food-producing species 
Cobalt trioxide All food-producing species 
Copper chloride All food-producing species 
Copper gluconate All food-producing species 
Copper heptanoate All food-producing species 
Copper methionate All food-producing species 
Copper oxide All food-producing species 
Copper sulphate All food-producing species 
Dicopper oxide All food-producing species 
Hydrochloric acid All food-producing species For use as excipient
Hydrogen peroxide All food-producing species 
Iodine and iodine inorganic compounds including:
— Sodium and potassium-iodide
— Sodium and potassium-iodate
— Iodophors including polyvinylpyrrolidone-iodine All food-producing species 
Iron dichloride All food-producing species 
Iron sulphate All food-producing species 
MagnesiumMagnesium sulphateMagnesium hydroxideMagnesium stearateMagnesium glutamateMagnesium orotateMagnesium aluminium silicateMagnesium oxideMagnesium carbonateMagnesium phosphateMagnesium glycerophosphateMagnesium aspartateMagnesium citrateMagnesium acetateMagnesium trisilicate All food-producing species 
Nickel gluconate All food-producing species 
Nickel sulphate All food-producing species 
Potassium DL-aspartate All food-producing species 
Potassium glucuronate All food-producing species 
Potassium glycerophosphate All food-producing species 
Potassium nitrate All food-producing species 
Potassium selenate All food-producing species 
Sodium chlorite Bovine For topical use only
Sodium dichloroisocyanurate Bovine, ovine, caprine For topical use only
Sodium hypophosphite All food-producing species 
Sodium selenate All food-producing species 
Sodium selenite All food-producing species 
Sulphur Bovine, porcine, ovine, caprine, equidae 
Zinc acetateZinc chlorideZinc gluconateZinc oleateZinc stearate All food-producing species 

2. Organic compounds

Pharmacologically active substance(s) Animal species Other provisions
17β-Oestradiol All mammalian food-producing species For therapeutic and zootechnical uses only
2-Aminoethanol All food-producing species 
2-Aminoethyl dihydrogenphosphate All food-producing species 
2-Pyrrolidone All food-producing species At parenteral doses up to 40 mg/kg bw
8-Hydroxyquinoline All mammalian food-producing species For topical use in newborn animals only
Acetyl cysteine All food-producing species 
Alfacalcidol Bovine For parturient cows only
Alfaprostol RabbitsBovine, porcine, equidae 
Bacitracin Bovine For intramammary use in lactating cows only and for all tissues except milk
Benzalkonium chloride All food-producing species For use as an excipient at concentrations up to 0,05 % only
Benzocaine All food-producing species For use as local anaesthetic only
Benzylalcohol All food-producing species For use as excipient
Betaine All food-producing species 
Bronopol Salmonidae For use only on farmed fertilised eggs
Brotizolam Bovine For therapeutic uses only
Buserelin All food-producing species 
Butorphanol tartrate Equidae For intravenous administration only
Butyl 4-hydroxybenzoate All food-producing species 
Butylscopolaminium bromide All food-producing species 
Caffeine All food-producing species 
Carbetocin All mammalian food-producing species 
Cefazolin BovineOvine, caprine For intramammary use, except if the udder may be used as food for human consumption
Cetostearyl alcohol All food-producing species 
Cetrimide All food-producing species 
Chlorhexidine All food-producing species For topical use only
Chlorocresol All food-producing species 
Clazuril Pigeon 
Cloprostenol Bovine, porcine, equidae 
Coco alkyl dimethyl betaines All food-producing species For use as excipient
Corticotropin All food-producing species 
D-Phe 6 -luteinising-hormone releasing hormone All food-producing species 
Dembrexine Equidae 
Denaverine hydrochloride Bovine 
Detomidine Bovine, equidae For therapeutic uses only
Diclazuril Ovine For oral use in lambs only
Diethyl phtalate All food-producing species 
Diethylene glycol monoethyl ether Bovine, porcine 
Dimanganese trioxide All food-producing species For oral use only
Dimethyl phtalate All food-producing species 
Dinoprost All mammalian food-producing species 
Dinoprost tromethamine All mammalian food-producing species 
Diprophylline All food-producing species 
Etamiphylline camsylate All food-producing species 
Ethanol All food-producing species For use as excipient
Ethyl lactate All food-producing species 
Etiproston tromethamine Bovine, porcine 
Fertirelin acetate Bovine 
Flumethrin Bees (honey) 
Folic acid All food-producing species 
Glycerol formal All food-producing species 
Gonadotrophin releasing hormone All food-producing species 
Heptaminol All food-producing species 
Hesperidin Equidae 
Hesperidin methyl chalcone Equidae 
Hexetidine Equidae For topical use only
Human chorion gonadotrophin All food-producing species 
Human menopausal urinary gonadotrophin Bovine 
Hydrocortisone All food-producing species For topical use only
Iodine organic compounds
— Iodoform All food-producing species 
Isobutane All food-producing species 
Isoflurane Equidae For use as anaesthetic only
Isoxsuprine Bovine, equidae For therapeutic use only in accordance with Council Directive 96/22/EEC (OJ L 125, 23.5.1996, p. 3)
Ketamine All food-producing species 
Ketanserin tartrate Equidae 
Ketoprofen Bovine, porcine, equidae 
L-tartaric acid and its mono- and di-basic salt of sodium, potassium and calcium All food-producing species For use as excipient
Lactic acid All food-producing species 
Lecirelin Bovine, equidae, rabbits 
Lobeline All food-producing species 
Luprostiol All mammalian species 
Malic acid All food-producing species For use as excipient
Manganese carbonate All food-producing species For oral use only
Manganese chloride All food-producing species For oral use only
Manganese gluconate All food-producing species For oral use only
Manganese glycerophosphate All food-producing species For oral use only
Manganese oxide All food-producing species For oral use only
Manganese pidolate All food-producing species For oral use only
Manganese ribonucleate All food-producing species For oral use only
Manganese sulphate All food-producing species For oral use only
Mecillinam Bovine For intrauterine use only
Medroxyprogesterone acetate Ovine For intravaginal use for zootechnical purposes only
Melatonin Ovine, caprine 
Menadione All food-producing species 
Menbutone Bovine, ovine, caprine, porcine, equidae 
Menthol All food-producing species 
Methyl nicotinate Bovine, equidae For topical use only
Mineral hydrocarbons, low to high viscosity including microcristalline waxes, approximately C10-C60; aliphatic, branched aliphatic and alicyclic compounds All food-producing species Excludes aromatic and unsaturated compounds
N-butane All food-producing species 
N-butanol All food-producing species For use as excipient
Natamycin Bovine, equidae For topical use only
Neostigmine All food-producing species 
Nicoboxil Equidae For topical use only
Nonivamide Equidae For topical use only
Oleyloleate All food-producing species For topical use only
Oxytocin All mammalian food-producing species 
Pancreatin All mammalian food-producing species For topical use only
Papain All food-producing species 
Papaverine Bovine Newborn calves only
Peracetic acid All food-producing species 
Phenol All food-producing species 
Phloroglucinol All food-producing species 
Phytomenadione All food-producing species 
Policresulen All food-producing species For topical use only
Polyethylene glycol 15 hydroxystearate All food-producing species For use as excipient
Polyethylene glycol 7 glyceryl cocoate All food-producing species For topical use only
Polyethylene glycol stearates with 8-40 oxyethylene units All food-producing species For use as excipient
Polysulphated glycosaminoglycan Equidae 
Praziquantel OvineEquidae For use in non-lactating sheep only
Pregnant mare serum gonadotrophin All food-producing species 
Prethcamide (crotethamide and cropropamide) All mammalian food-producing species 
Procaine All food-producing species 
Propane All food-producing species 
Propylene glycol All food-producing species 
Quatresin All food-producing species For use as preservative only at concentrations of up to 0,5 %
R-Cloprostenol Bovine, porcine, equidae 
Rifaximin All mammalian food-producing speciesBovine For topical use onlyFor intramammary use, except if the udder may be used as food for human consumption, and intrauterine use only
Romifidine Equidae For therapeutic uses only
Sodium 2-methyl-2-phenoxy-propanoate Bovine, porcine, caprine, equidae 
Sodium benzyl 4-hydroxybenzoate All food-producing species 
Sodium butyl 4-hydroxybenzoate All food-producing species 
Sodium cetostearyl sulphate All food-producing species For topical use only
Somatosalm Salmon 
Tanninum All food-producing species 
Tau fluvalinate  
Terpin hydrate Bovine, porcine, ovine, caprine 
Tetracaine All food-producing species For use as anaesthetic only
Theobromine All food-producing species 
Theophylline All food-producing species 
Thiomersal All food-producing species For use only as preservatives in multidose vaccines at a concentration not exceeding 0,02 %
Thymol All food-producing species 
Timerfonate All food-producing species For use only as preservatives in multidose vaccines at a concentration not exceeding 0,02 %
Trimethylphloroglucinol All food-producing species 
Vitamin D All food-producing species 
Wool alcohols All food-producing species For topical use only

3. Substances generally recognised as safe

Pharmacologically active substance(s) Animal species Other provisions
Absinthium extract All food-producing species 
Acetylmethionine All food-producing species 
Aluminium hydroxide All food-producing species 
Aluminium monostearate All food-producing species 
Ammonium sulfate All food-producing species 
Benzyl benzoate All food-producing species 
Benzyl p-hydroxybenzoate All food-producing species 
Calcium borogluconate All food-producing species 
Calcium citrate All food-producing species 
Camphor All food-producing species External use only
Cardamon extract All food-producing species 
Diethyl sebacate All food-producing species 
Dimethicone All food-producing species 
Dimethyl acetamide All food-producing species 
Dimethyl sulphoxide All food-producing species 
Epinephrine All food-producing species 
Ethyl oleate All food-producing species 
Ethylenediaminetetraacetic acid and salts All food-producing species 
Eucalyptol All food-producing species 
Follicle stimulating hormone (natural FSH from all species and their synthetic analogues) All food-producing species 
Formaldehyde All food-producing species 
Formic acid All food-producing species 
Glutaraldehyde All food-producing species 
Guaiacol All food-producing species 
Heparin and its salts All food-producing species 
Human chorionic gonadotropin (natural HCG and its synthetic analogues) All food-producing species 
Iron ammonium citrate All food-producing species 
Iron dextran All food-producing species 
Iron glucoheptonate All food-producing species 
Isopropanol All food-producing species 
Lanolin All food-producing species 
Luteinising hormone (natural LH from all species and their synthetic analogues) All food-producing species 
Magnesium chloride All food-producing species 
Magnesium gluconate All food-producing species 
Magnesium hypophosphite All food-producing species 
Mannitol All food-producing species 
Methylbenzoate All food-producing species 
Monothioglycerol All food-producing species 
Montanide All food-producing species 
Myglyol All food-producing species 
Orgotein All food-producing species 
Poloxalene All food-producing species 
Poloxamer All food-producing species 
Polyethylene glycols (molecular weight ranging from 200 to 10 000) All food-producing species 
Polysorbate 80 All food-producing species 
Serotonin All food-producing species 
Sodium chloride All food-producing species 
Sodium cromoglycate All food-producing species 
Sodium dioctylsulphosuccinate All food-producing species 
Sodium formaldehydesulphoxylate All food-producing species 
Sodium lauryl sulphate All food-producing species 
Sodium pyrosulphite All food-producing species 
Sodium stearate All food-producing species 
Sodium thiosulphate All food-producing species 
Tragacanth All food-producing species 
Urea All food-producing species 
Zinc oxide All food-producing species 
Zinc sulphate All food-producing species 

4. Substances used in homeopathic veterinary medicinal products

Pharmacologically active substance(s) Animal species Other provisions
All substances used in homeopathic veterinary medicinal products provided that their concentration in the product does not exceed one part per ten thousand All food-producing species 

5. Substances used as food additives in foodstuffs for human consumption

Pharmacologically active substance(s) Animal species Other provisions
Substances with an E number All food-producing species Only substances approved as additives in foodstuffs for human consumption, with the exception of preservatives listed in part C of Annex III to European Parliament and Council Directive 95/2/EC (OJ L 61, 18.3.1995, p. 1).

6. Substances of vegetable origin

Pharmacologically active substance(s) Animal species Other provisions
Angelicae radix aetheroleum All food-producing species 
Anisi aetheroleum All food-producing species 
Balsamum peruvianum All food-producing species For topical use only
Carvi aetheroleum All food-producing species 
Caryophylli aetheroleum All food-producing species 
Chrysanthemi cinerariifolii flos All food-producing species For topical use only
Cinnamomi cassiae aetheroleum All food-producing species 
Cinnamomi ceylanici aetheroleum All food-producing species 
Citri aetheroleum All food-producing species 
Citronellae aetheroleum All food-producing species 
Coriandri aetheroleum All food-producing species 
Echinacea purpurea All food-producing species For topical use only
Eucalypti aetheroleum All food-producing species 
Foeniculi aetheroleum All food-producing species 
Hamamelis virginiana All food-producing species For topical use only
Hyperici oleum All food-producing species For topical use only
Lespedeza capitata All food-producing species 
Lini oleum All food-producing species 
Majoranae herba All food-producing species 
Matricariae flos All food-producing species 
Medicago sativa extractum All food-producing species For topical use only
Melissae folium All food-producing species 
Menthae piperitae aetheroleum All food-producing species 
Millefolii herba All food-producing species 
Myristicae aetheroleum All food-producing species For use in newborn animals only
Oxidation products of Terebinthinae oleum Bovine, porcine, ovine, caprine 
Pyrethrum extract All food-producing species For topical use only
Quercus cortex All food-producing species 
Quillaia saponins All food-producing species 
Ricini oleum All food-producing species For use as excipient
Rosmarini aetheroleum All food-producing species 
Rosmarini folium All food-producing species 
Salviae folium All food-producing species 
Sambuci flos All food-producing species 
Sinapis nigrae semen All food-producing species 
Terebinthinae aetheroleum rectificatum All food-producing species For topical use only
Terebinthinae laricina All food-producing species For topical use only
Thymi aetheroleum All food-producing species 
Tiliae flos All food-producing species 
Urticae herba All food-producing species 

ANNEX III
LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES USED IN VETERINARY MEDICINAL PRODUCTS FOR WHICH PROVISIONAL MAXIMUM RESIDUE LIMITS HAVE BEEN FIXED

1. Anti-infectious agents
 1.1. Chemotheurapeutics
 1.1.2. Benzenesulphonamides

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Clorsulon Clorsulon Bovine 50 μg/kg Muscle Provisional MRLs expire on 1 January 2000
   150 μg/kg Liver 
   400 μg/kg Kidney 
 1.2. Antibiotics
 1.2.1. Beta-lactamase inhibitors

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Clavulanic acid Clavulanic acid Bovine, ovine 200 μg/kg Milk Provisional MRLs expire on 1 July 1999
  Bovine, ovine, porcine 200 μg/kg Muscle 
   200 μg/kg Fat 
   200 μg/kg Liver 
   200 μg/kg Kidney 
 1.2.2. Macrolides

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Erythromycin MRLs apply to all microbiological active residues expressed as erythromycin equivalent Bovine, ovine 40 μg/kg Milk Provisional MRLs expire on 1 June 2000
  Bovine, ovine, porcine, poultry 400 μg/kg Muscle 
   400 μg/kg Fat 
   400 μg/kg Liver 
   400 μg/kg Kidney 
  Poultry 200 μg/kg Eggs 
Josamycin Josamycin Chicken 200 μg/kg Muscle Provisional MRLs expire on 1 July 2000
   200 μg/kg Fat 
   200 μg/kg Liver 
   400 μg/kg Kidney 
   200 μg/kg Eggs 
 1.2.5. Aminoglycosides

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Aminosidine Aminosidine Bovine, porcine, rabbits, chicken 500 μg/kg Muscle Provisional MRLs expire on 1 July 2000
   1 500 μg/kg Liver 
   1 500 μg/kg Kidney 
Apramycin Apramycin Bovine 1 000 μg/kg Muscle Provisional MRLs expire on 1 July 1999
  For use in non-lactating cattle only 1 000 μg/kg Fat 
   10 000 μg/kg Liver 
   20 000 μg/kg Kidney 
  Porcine 1 000 μg/kg Muscle 
   1 000 μg/kg Skin and fat 
   1 000 μg/kg Liver 
   5 000 μg/kg Kidney 
Dihydrostreptomycin Dihydrostreptomycin Bovine, ovine 200 μg/kg Milk Provisional MRLs expire on 1 June 2000
  Bovine, ovine, porcine, poultry 500 μg/kg Muscle 
   500 μg/kg Fat 
   500 μg/kg Liver 
   1 000 μg/kg Kidney 
Gentamicin Gentamicin Bovine 100 μg/kg Milk Provisional MRLs expire on 1 June 2000
  Bovine, porcine 100 μg/kg Muscle 
   100 μg/kg Fat 
   200 μg/kg Liver 
   1 000 μg/kg Kidney 
Neomycin (including framycetin) Neomycin Bovine, ovine, caprine 500 μg/kg Milk Provisional MRLs expire on 1 June 2000
  Bovine, ovine, caprine, porcine, chicken, turkey, duck 500 μg/kg Muscle 
   500 μg/kg Fat 
   500 μg/kg Liver 
   5 000 μg/kg Kidney 
  Chicken 500 μg/kg Eggs 
Spectinomycin Spectinomycin Bovine 200 μg/kg Milk Provisional MRLs expire on 1 July 2000
  Bovine, porcine, poultry 300 μg/kg Muscle 
   500 μg/kg Fat 
   2 000 μg/kg Liver 
   5 000 μg/kg Kidney 
Streptomycin Streptomycin Bovine, ovine 200 μg/kg Milk Provisional MRLs expire on 1 June 2000
  Bovine, ovine, porcine, poultry 500 μg/kg Muscle 
   500 μg/kg Fat 
   500 μg/kg Liver 
   1 000 μg/kg Kidney 
 1.2.6. Quinolones

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Decoquinate Decoquinate Bovine, ovine 500 μg/kg Muscle Provisional MRLs expire on 1 July 2000
   500 μg/kg Fat 
   500 μg/kg Liver 
   500 μg/kg Kidney 
Enrofloxacin Sum of enrofloxacin and ciprofloxacin Ovine 100 μg/kg Muscle Provisional MRLs expire on 1 July 1999
   100 μg/kg Fat 
   300 μg/kg Liver 
   200 μg/kg Kidney 
Flumequine Flumequine Bovine, ovine, porcine, chicken 50 μg/kg Muscle Provisional MRLs expire on 1 January 2000
   50 μg/kg Fat or skin and fat 
   100 μg/kg Liver 
   300 μg/kg Kidney 
  Salmonidae 150 μg/kg Muscle and skin 
Marbofloxacin Marbofloxacin Bovine 150 μg/kg Muscle Provisional MRLs expire on 1 July 2000
   50 μg/kg Fat 
   150 μg/kg Liver 
   150 μg/kg Kidney 
   75 μg/kg Milk 
  Porcine 150 μg/kg Muscle 
   50 μg/kg Skin and fat 
   150 μg/kg Liver 
   150 μg/kg Kidney 
 1.2.9. Polymyxins

Phamarcologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Colistin Colistin Bovine, ovine 50 μg/kg Milk Provisional MRLs expire on 1 July 2000
  Bovine, ovine, porcine, chicken, rabbits 150 μg/kg Muscle 
   150 μg/kg Fat 
   150 μg/kg Liver 
   200 μg/kg Kidney 
  Chicken 300 μg/kg Eggs 
 1.2.10. Penicillins

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Penethamate Benzylpenicillin Ovine 50 μg/kg Muscle Provisional MRLs expire on 1 January 2000
   50 μg/kg Fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
   4 μg/kg Milk 
  Porcine 50 μg/kg Muscle 
   50 μg/kg Fat 
   50 μg/kg Liver 
   50 μg/kg Kidney 
 1.2.11. Florfenicol and related compounds

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Florfenicol Sum of florfenicol and its metabolites measured as florfenicol-amine Fish 1 000 μg/kg Muscle and skin in natural proportions Provisional MRLs expire on 1 July 2001

2. Antiparasitic agents
 2.1. Agents acting against endoparasites
 2.1.2. Benzimidazoles and pro-benzimidazoles

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Albendazole sulphoxide Sum of albendazole, albendazole sulphoxide, albendazole sulphone, and albendazole 2-amino sulphone, expressed as albendazole Bovine, ovine 100 μg/kg Milk Provisional MRLs expire on 1 January 2000
  Bovine, ovine, pheasant 100 μg/kg Muscle 
   100 μg/kg Fat 
   1 000 μg/kg Liver 
   500 μg/kg Kidney 
Netobimin Sum of netobimin and albendazole and metabolites of albendazole measured as 2-amino- benzimidazole sulphone Bovine, ovine, caprine 100 μg/kg Muscle Provisional MRLs expire on 31 July 1999
   100 μg/kg Fat 
   1 000 μg/kg Liver 
   500 μg/kg Kidney 
   100 μg/kg Milk 
 2.2. Agents acting against ectoparasites
 2.2.1. Formamidines

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Amitraz Sum of amitraz and all metabolites containing the 2,4-DMA moeity, expressed as amitraz Bees 200 μg/kg Honey Provisional MRLs expire on 1 July 1999
 2.2.2. Iminophenyl thiazolidine derivative

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Cymiazole Cymiazole Bees 1 000 μg/kg Honey Provisional MRLs expire on 1 July 1999
 2.2.3. Pyretrin and pyrethroids

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Cyfluthrin Cyfluthrin Bovine 10 μg/kg Muscle Provisional MRLs expire on 1 January 2001
   50 μg/kg Fat 
   10 μg/kg Liver 
   10 μg/kg Kidney 
   20 μg/kg Milk 
    Further provisions in Council Directive 94/29/EC are to be observed (OJ L 189, 23.7.1994, p. 67) 
 2.2.4. Organophosphates

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Azamethiphos Azamethiphos Salmonidae 100 μg/kg Muscle and skin in natural proportions Provisional MRLs expire on 1 June 1999
 2.2.5. Acyl urea derivates

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Teflubenzuron Teflubenzuron Salmonidae 500 μg/kg Muscle and skin in natural proportions Provisional MRLs expire on 1 July 1999
 2.3. Agents acting against endo- and ectoparasites
 2.3.1. Avermectins

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Moxidectin Moxidectin Equidae 50 μg/kg Muscle Provisional MRLs expire on 1 January 2000
   500 μg/kg Fat 
   100 μg/kg Liver 
   50 μg/kg Kidney 

3. Agents acting on the nervous system
 3.2. Agents acting on the autonomic nervous system
 3.2.1. β 2 sympathomimetic agents

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Clenbuterol hydrochloride Clenbuterol Bovine 0,1 μg/kg Muscle Provisional MRLs expire on 1 July 2000
  Indication: solely for tocolysis in parturient cows 0,5 μg/kg Liver 
   0,5 μg/kg Kidney 
   0,05 μg/kg Milk 
  Equidae 0,1 μg/kg Muscle 
  Indications: tocolysis and the treatment of respiratory ailments 0,5 μg/kg Liver 
   0,5 μg/kg Kidney 

5. Anti-inflammatory agents
 5.1. Nonsteroidal anti-inflammatory agents
 5.1.1. Arylpropionic acid derivative

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Carprofen Carprofen Bovine 500 μg/kg Muscle Provisional MRLs expire on 1 January 2000
   500 μg/kg Fat 
   1 000 μg/kg Liver 
   1 000 μg/kg Kidney 
  Equidae 50 μg/kg Muscle 
   100 μg/kg Fat 
   1 000 μg/kg Liver 
   1 000 μg/kg Kidney 
 5.1.2. Enolic acid derivates

Pharmacologically active substance(s) Marker residue Animal species MRLs Target tissues Other provisions
Meloxicam Meloxicam Bovine 25 μg/kg Muscle Provisional MRLs expire on 1 January 2000
   60 μg/kg Liver 
   35 μg/kg Kidney 

ANNEX IV
LIST OF PHARMACOLOGICALLY ACTIVE SUBSTANCES FOR WHICH NO MAXIMUM LEVELS CAN BE FIXED

Pharmacologically active substance(s)
Aristolochia spp. and preparations thereof
Chloramphenicol
Chloroform
Chlorpromazine
Colchicine
Dapsone
Dimetridazole
Metronidazole
Nitrofurans (including furazolidone)
Ronidazole