
Article 1 
The substances specified in the Annex, belonging to the additive category ‘sensory additives’ and to the functional group ‘flavouring compounds’, are authorised as feed additives in animal nutrition subject to the conditions laid down in that Annex.
Article 2 
The authorisation of disodium 5′-ribonucleotides, disodium 5′-guanylate and disodium 5′-inosinate produced by fermentation is denied.
Article 3 

1. The substances specified in the Annex and the substances mentioned in Article 2, and premixtures containing those substances and which are produced and labelled before 15 December 2018 in accordance with the rules applicable before 15 March 2018 may continue to be placed on the market and used until the existing stocks are exhausted.
2. Compound feed and feed materials containing the substances as specified in the Annex and the substances mentioned in Article 2 which are produced and labelled before 15 September 2019 in accordance with the rules applicable before 15 March 2018 may continue to be placed on the market and used until the existing stocks are exhausted if they are intended for food-producing animals.
3. Compound feed and feed materials containing the substances as specified in the Annex and the substances mentioned in Article 2 which are produced and labelled before 15 September 2020 in accordance with the rules applicable before 15 March 2018 may continue to be placed on the market and used until the existing stocks are exhausted if they are intended for non-food-producing animals.
Article 4 
This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union.
This Regulation shall be binding in its entirety and directly applicable in all Member States.Done at Brussels, 15 February 2018.
For the Commission
The President
Jean-Claude JUNCKER
ANNEX

Identification number of the additive Name of the holder of authorisation Additive Composition, chemical formula, description, analytical method Species or category of animal Maximum age Minimum content Maximum content Other provisions End of period of authorisation
mg of active substance/kg of complete feedingstuff with a moisture content of 12 %
Category: Sensory additives. Functional group: Flavouring compounds
2b635 — Disodium 5′-ribonucleotide 
Disodium 5′-ribonucleotides

Disodium 5′-ribonucleotides: a mixture of disodium 5′-guanylate (GMP) and disodium 5′-inosinate (IMP).

Produced by RNA hydrolysis

Purity: min.: 97 % assay

Chemical formula:


— C10H11N4O8P · nH2O
— C10H12N5Na2O8P · nH2O

For the identification of GMP and IMP in the feed additive:

JECFA monograph, Specifications for food additives: Disodium 5′-Ribonucleotides.

For the determination of GMP and IMP in the feed additive and premixtures of flavourings:

High performance Liquid Chromatography coupled to UV detection (HPLC-UV).
 All animal species — — — 
1. The additive shall be incorporated into the feed in the form of a premixture.

2. In the directions for use of the additive and premixtures, the storage and stability conditions shall be indicated.

3. 
50 mg/kg of complete feedingstuff with a moisture content of 12 %.

4. 
'Recommended maximum content of the active substance or the combination of disodium 5′-ribonucleotide, disodium 5′-guanylate and disodium 5′-inosinate of complete feedingstuff with a moisture content of 12 %: 50 mg/kg'.

5. The functional group, the identification number, the name and the added amount of the active substance shall be indicated on the label of premixtures and on the labelling of feed materials and compound feedingstuffs, if the following content of the active substance or the combination of disodium 5′-ribonucleotide, disodium 5′-guanylate and disodium 5′-inosinate in complete feedingstuff with a moisture content of 12 % is exceeded: 50 mg/kg.

6. For users of the additive and premixtures, feed business operators shall establish operational procedures and organisational measures to address potential risks by inhalation, dermal contact or eyes contact. Where those risks cannot be eliminated or reduced to a minimum by such procedures and measures, the additive and premixtures shall be used with personal protective equipment, including breathing protection, safety glasses and gloves.
 15.3.2028
2b627 — Disodium 5′-guanylate 
Disodium 5′-guanylate (GMP)

Disodium 5′-guanylate

Produced by RNA hydrolysis

Purity: min.: 97 % assay

Chemical formula: C10H12N5Na2O8P · n H2O

CAS number: 5550-12-9

For the identification of GMP in the feed additive:

JECFA monograph, Specifications for food additives: Disodium 5′-Ribonucleotides.

For the determination of GMP in the feed additive and premixtures of flavourings:

High performance Liquid Chromatography coupled to UV detection (HPLC-UV).
 All animal species — — — 
1. The additive shall be incorporated into the feed in the form of a premixture.

2. In the directions for use of the additive and premixtures, the storage and stability conditions shall be indicated.

3. 
50 mg/kg of complete feedingstuff with a moisture content of 12 %.

4. 
'Recommended maximum content of the active substance or the combination of disodium 5′-ribonucleotide, disodium 5′-guanylate and disodium 5′-inosinate of complete feedingstuff with a moisture content of 12 %: 50 mg/kg'.

5. The functional group, the identification number, the name and the added amount of the active substance shall be indicated on the label of premixtures and on the labelling of feed materials and compound feedingstuffs, if the following content of the active substance or the combination of disodium 5′-ribonucleotide disodium 5′-guanylate and disodium 5′-inosinate in complete feedingstuff with a moisture content of 12 % is exceeded: 50 mg/kg.

6. For users of the additive and premixtures, feed business operators shall establish operational procedures and organisational measures to address potential risks by inhalation, dermal contact or eyes contact. Where those risks cannot be eliminated or reduced to a minimum by such procedures and measures, the additive and premixtures shall be used with personal protective equipment, including breathing protection, safety glasses and gloves.
 15.3.2028
2b631 — Disodium 5′-inosinate 
Disodium 5′-inosinate (IMP)

Disodium 5′-inosinate

Produced by RNA hydrolysis

Purity: min. 97 % assay

Chemical formula: C10H11 N4O8P · nH2O

CAS number 4691-65-0

For the identification of IMP in the feed additive:

JECFA monograph, Specifications for food additives: Disodium 5′-Ribonucleotides.

For the determination of IMP in the feed additive and premixtures of flavourings:

High performance Liquid Chromatography coupled to UV detection (HPLC-UV).
 All animal species — — — 
1. The additive shall be incorporated into the feed in the form of a premixture.

2. In the directions for use of the additive and premixtures, the storage and stability conditions shall be indicated.

3. 
50 mg/kg of complete feedingstuff with a moisture content of 12 %.

4. 
'Recommended maximum content of the active substance or the combination of disodium 5′-ribonucleotide, disodium 5′-guanylate and disodium 5′-inosinate of complete feedingstuff with a moisture content of 12 %: 50 mg/kg'.

5. The functional group, the identification number, the name and the added amount of the active substance shall be indicated on the label of premixtures and on the labelling of feed materials and compound feedingstuffs, if the following content of the active substance or the combination of disodium 5′-ribonucleotide, disodium 5′-guanylate and disodium 5′-inosinate in complete feedingstuff with a moisture content of 12 % is exceeded: 50 mg/kg.

6. For users of the additive and premixtures, feed business operators shall establish operational procedures and organisational measures to address potential risks by inhalation, dermal contact or eyes contact. Where those risks cannot be eliminated or reduced to a minimum by such procedures and measures, the additive and premixtures shall be used with personal protective equipment, including breathing protection, safety glasses and gloves.
 15.3.2028
